Demi Moore’s shocking snub at the 2025 Academy Awards had social media buzzing—but it wasn’t just the actress’ reaction that caught viewers’ attention. 

Sitting directly behind Moore during the ceremony was musician and producer Jack Antonoff, whose response to the unexpected loss quickly went viral.

The Ghost star, 62, was a strong contender for Best Actress thanks to her powerful performance in Substance.

Many believed this could mark a major career milestone, potentially earning Moore her first-ever Oscar.

However, when the winner was announced, it was 25-year-old Mikey Madison who took home the award for her role in Anora, leaving Moore visibly stunned.

Demi Moore’s Disappointed Reaction Caught on Camera

As the cameras panned to the nominees during the big reveal, Moore appeared tense, clearly anticipating the possibility of a win. But the moment Madison’s name was called, her expression quickly shifted—her jaw tightened, and she muttered what seemed to be a resigned “Nice.” Though she remained composed, it was evident that the loss came as a disappointment.

Jack Antonoff’s Priceless Expression Steals the Spotlight

While Moore’s reaction was noteworthy, it was Jack Antonoff’s response that truly set social media ablaze. The Grammy-winning musician, known for his collaborations with Taylor Swift and Lana Del Rey, was seated directly behind Moore. As soon as Madison’s name was announced, Antonoff’s face said it all—his eyes widened, his lips formed an exaggerated “O” shape, and he immediately turned to his wife, actress Margaret Qualley, in apparent disbelief.

Qualley, who co-starred alongside Moore in Substance, also seemed surprised but kept her reaction more subdued. Meanwhile, Antonoff’s comically exaggerated expression was caught on camera and quickly spread across the internet, turning him into an unexpected meme of the night.

Social Media Reacts: ‘Jack Antonoff’s Face Says It All’

Viewers wasted no time in sharing the moment online, with many X (formerly Twitter) users posting clips of Antonoff’s reaction alongside humorous captions.

“Jack Antonoff’s reaction to Mikey Madison winning Best Actress over Demi Moore 😭😭😭,” one user wrote, along with a looped video of his stunned expression.

Another added: “No but Jack Antonoff’s reaction to Mikey winning that Oscar is so funny.”

“Jack Antonoff’s face when Demi lost… please 😭😭😭 #Oscars,” someone else chimed in.

Within hours, memes and GIFs of Antonoff’s reaction flooded social media, making him an unexpected highlight of the night.

Demi Moore’s Oscar Journey: A Career-Defining Role?

Many fans and critics had high hopes for Moore’s performance in Substance, a film that was widely praised for showcasing a new depth to her acting abilities. The role was considered a major comeback for the actress, whose Hollywood career spans decades but has yet to include an Academy Award win.

Though Moore remained gracious in defeat, the disappointment was understandable. Having been a major force in Hollywood since the 1980s, an Oscar victory would have been a well-earned recognition of her talent and longevity in the industry.

Mikey Madison’s Surprise Win

Meanwhile, Madison’s win was seen as a breakthrough moment for the young actress. Her portrayal in Anora had been critically acclaimed, though many expected the award to go to a more seasoned performer.

In the end, her victory proved that the Academy wasn’t afraid to reward fresh talent, even when up against industry veterans like Moore.

Jack Antonoff: The Internet’s Favorite Reaction King

While the Oscars are always filled with emotional highs and lows, it’s rare for someone in the audience to steal the spotlight. Antonoff’s unfiltered reaction became an instant viral moment, reminding viewers that even celebrities get caught off guard during Hollywood’s biggest night.

Whether intentional or not, Antonoff has now joined the ranks of memorable awards show reactions—right up there with Nicole Kidman’s infamous clapping and Meryl Streep’s enthusiastic cheer.

As for Demi Moore, while she may have missed out on an Oscar this time, her performance in Substance has undoubtedly reaffirmed her status as a Hollywood powerhouse. And who knows? Maybe next year, it will be her turn to take home the coveted gold statue—hopefully without Jack Antonoff’s meme-worthy reaction stealing the show.